STUDY OF THE WIDELY USED ETHYLCELLULOSE POLYMER AS FILM FORMING AND MATRIX FORMER AGENT Ph.D. Thesis
نویسندگان
چکیده
The aim of our research was to investigate theeffect of the length of the polymer chain and the concen-tration of triethyl citrate used as a plasticizer on the thermalstability of the film structure in the case of two ethyl cel-lulose films (EC 10 and EC 45) used for preparing MRdosage forms. The influence of storage time was studied bymonitoring the changes in the thermoanalytical parametersand by performing TG–MS examinations. It was found thatthe decomposition of the plasticizer from the arising filmstructure is retarded and a more homogeneous sample,therefore a better film can be prepared from EC 45. Massspectrography performed as a coupled technique alsoproved that the films stayed stable until approximately200 C. Based on the above results, the composition pre-pared from EC 45 polymer with 5% triethyl citrate asplasticizer is recommended for making MR dosage forms.
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